Synaptic and Circuit Mechanisms of Fragile X
Altered Neuronal and Circuit Excitability in Fragile X Syndrome
Neuron
August 2015
Contractor A, Klyachko VA, and Portera-Cailliau C
Channelopathies in fragile X syndrome
Nature Reviews Neuroscience
April 2021
Deng PY, and Klyachko VA
Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome
Cell Reports
November 2018
Cheng C, Deng PY, Ikeuchi Y, Yuede C, Li D, Rensing N, Huang J, Baldridge D, Maloney SE, Dougherty JD, Constantino J, Jahani-Asi A, Wong M, Wozniak DF, Wang T, Klyachko VA, and Bonni A
FMRP regulates GABAa receptor channel activity to control signal integration in hippocampal granule cells
Cell Reports
May 2022
Deng PY, Kumar A, Cavalli V, and Klyachko VA
FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels
Neuron
February 2013
Deng PY, Rotman Z, Blundon JA, Cho Y, Cui J, Cavalli V, Zakharenko SS, and Klyachko VA
GABAb receptor-mediated feed-forward circuit dysfunction in the mouse model of fragile X syndrome
The Journal of Physiology
November 2015
Wahlstrom-Helgren S, and Klyachko VA
Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects i a mouse model of fragile X syndrome
The Journal of Physiology
January 2016
Deng PY, and Klyachko VA
Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice
Cell Reports
September 2016
Deng PY, and Klyachko VA
Independent role for presynaptic FMRP revealed by and FMR1 missense mutation associated with intellectual disability and seizures
Proc Natl Acad USA
January 2015
Myrick LK, Deng PY, Hashimoto H, Oh YM, Cho Y, Poidevin MJ, Suhl JA, Visootsak J, Cavalli V, Jin P, Cheng X, Warren ST, and Klyachko VA
Voltage-Independent SK-Channel Dysfunction Causes Neuronal Hyperexcitability in the Hippocampus of Fmr1 Knock-Out Mice
Journal of Neuroscience
January 2019
Deng PY, Carlin D, Oh YM, Myrick LK, Warren ST, Cavalli V, and Klyachko VA